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Ethyl 3-(bromomethyl)-2-chloroisonicotinate → 4-chloro-2-(1-(4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 3-(bromomethyl)-2-chloroisonicotinate | HCID 89874240 | — |
| 反応物 | 1-(4-Methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethanamine hydrochloride | HCID 89874857 | — |
| 生成物 | 4-chloro-2-(1-(4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one | HCID 89875433 | 78% |
反応手順
The title compound is prepared in 78% yield (320 mg, pale brown solid) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (300 mg, 1.1 mmol, Step-1 of Intermediate-1) and 1-(4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethanamine hydrochloride (330 mg, 1.1 mmol, Amine-49, single enantiomer) in a similar manner to Intermediate-2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09187475B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-203762ba02734a65855b47ff9d842446 |
| 出典メモ | uspto-grants-2015_11 |