2-Bromoethanol → N4-(3,4-ethylenedioxyphenyl)-N2-[3-(hydroxyethylamino)phenyl]-5-fluoro-2,4-pyrimidinediamine

HRID 71528

反応式

HRID 71528 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:21]=[CH:20][C:19]4[O:22][CH2:23][CH2:24][O:25][C:18]=4[CH:17]=3)[C:12]([F:26])=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.Br[CH2:28][CH2:29][OH:30]>>[CH2:24]1[CH2:23][O:22][C:19]2[CH:20]=[CH:21][C:16]([NH:15][C:13]3[C:12]([F:26])=[CH:11][N:10]=[C:9]([NH:8][C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][CH2:28][CH2:29][OH:30])[CH:3]=4)[N:14]=3)=[CH:17][C:18]=2[O:25]1

参加物

3

反応物 2

HCID 108982-BromoethanolHCID 22060661N2-(3-Aminophenyl)-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-2,4-pyrimidinediamine

生成物 1

HCID 66758538N4-(3,4-ethylenedioxyphenyl)-N2-[3-(hydroxyethylamino)phenyl]-5-fluoro-2,4-pyrimidinediamine

実験手順

N2-(3-Aminophenyl)-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-2,4-pyrimidinediamine and 2-bromoethanol were reacted together to give N4-(3,4-ethylenedioxyphenyl)-N2-[3-(hydroxyethylamino)phenyl]-5-fluoro-2,4-pyrimidinediamine. LCMS: ret. time: 15.44 min.; purity: 98.6%; MS (m/e): 398.05 (MH+).

出典と根拠

ORDレコード
ord-f13e0b0de8324129b0ee89134561819e
出典データセット
uspto-grants-2014_09
特許番号
US08822685B2

関連ノート

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