Methanol → Methyl p-aminosalicylate

HRID 71535

反応式

HRID 71535 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:11])[CH:3]=1.[CH3:12]O>>[OH:11][C:4]1[CH:3]=[C:2]([CH:10]=[CH:9][C:5]=1[C:6]([O:8][CH3:12])=[O:7])[NH2:1]

参加物

3

反応物 2

HCID 887MethanolHCID 46494-Aminosalicylic Acid

生成物 1

HCID 77787Methyl p-aminosalicylate

実験手順

A solution of 4-amino-2-hydroxybenzoic acid (1 g, 6.5 mmol) in MeOH (15 mL) and concentrated sulfonic acid (1 mL) was refluxed overnight. The reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL). The organic layer was separated, dried, evaporated to give 3-hydroxy-4-methoxycarbonylaniline.

後処理

  1. customThe reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL)
  2. customThe organic layer was separated
  3. customdried
  4. customevaporated

出典と根拠

ORDレコード
ord-aba6bdb960ce41dead32062ee1bf5d05
出典データセット
uspto-grants-2014_09
特許番号
US08822685B2

関連ノート

読み込み中…