Decylamine → Methyl 3-chloro-4-(2,2-difluoropropoxy)benzoate

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[OH:12])[C:5]([O:7][CH3:8])=[O:6].FC(F)(F)S(O[CH2:19][C:20]([F:23])([F:22])[CH3:21])(=O)=O.CCCCCCCCCCN>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[O:12][CH2:19][C:20]([F:23])([F:22])[CH3:21])[C:5]([O:7][CH3:8])=[O:6]

参加物

反応物 3

HCID 8916Decylamine

HCID 77580Methyl 3-chloro-4-hydroxybenzoate

HCID 587470122,2-Difluoropropyl 1,1,1-trifluoromethanesulfonate

生成物 1

HCID 89874714Methyl 3-chloro-4-(2,2-difluoropropoxy)benzoate収率 54%

実験手順

The title compound is prepared in 54% yield (1.54 g, white solid) from methyl 3-chloro-4-hydroxybenzoate (2.00 g, 10.7 mmol) and 2,2-difluoropropyl trifluoromethanesulfonate (6.11 g, 26.8 mmol) in a similar manner to Step-1 of Amine-10.

出典と根拠

ORDレコード: ord-fbd6336f696e4a788dbae0a198b9b22b
出典データセット: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09187475B2

反応ノート

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