Acetyl chloride → HCID 178496609、化合物

HRID 715678ノート

反応式

HRID 715678 の反応式
C(OC([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][CH3:16])[CH2:11][CH2:10]1)=O)(C)(C)C.C(Cl)(=O)C>C(O)C>[CH3:16][O:15][C@H:12]1[CH2:13][CH2:14][C@H:9]([NH2:8])[CH2:10][CH2:11]1

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 178496620HCID 178496620、化合物

生成物 1

HCID 178496609HCID 178496609、化合物収率 126.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
0 °C

実験手順

trans-(tert-Butoxy)-N-(4-methoxycyclohexyl)carboxamide (642 mg, 2.80 mmol) was dissolved in ethanol (5 mL) and cooled to 0° C. Acetyl chloride (1.5 mL) was added and the reaction was allowed to reach room temperature and stirred overnight. Solvent was removed in vacuo to give the desired product (458 mg, quantitative yield) as a hydrochloride salt. ES-MS: 130 (M+1).

後処理

  1. customto reach room temperature
  2. customSolvent was removed in vacuo

出典と根拠

ORDレコード
ord-94632281bd1f420d8102bb504d6fc025
出典データセット
uspto-grants-2015_11
特許番号
US09187479B2

反応ノート

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