Potassium Carbonate → 4-Methoxy-3-(3-morpholinopropoxy)benzonitrile

5 g 3-Morpholine-4-yl-propan-1-ol was dissolved in dichloromethane, cooled to 0° C., 3.25 mL methanesulfonylchloride was added and the mixture was stirred for 2 h at ambient temperature. Then 7 g potassium carbonate and 3-hydroxy-4-methoxybenzonitrile were added and the reaction was stirred at 45° C. for 3 h. The mixture was concentrated and 70 mL dimethylacetamide was added and stirred at 120° C. for 3 h. After this time, the mixture was diluted with dichloromethane and extracted with water, the organic phase was dried over magnesium sulfate and concentrated.

1. stirringthe reaction was stirred at 45° C. for 3 h
2. concentrationThe mixture was concentrated
3. addition70 mL dimethylacetamide was added
4. stirringstirred at 120° C. for 3 h
5. additionAfter this time, the mixture was diluted with dichloromethane
6. extractionextracted with water
7. dry with materialthe organic phase was dried over magnesium sulfate
8. concentrationconcentrated

ORDレコード

ord-7af5c63f4222416bbf2ffc0f49886eaf

出典データセット

uspto-grants-2015_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09187478B2