2-Bromopropane → HCID 53399549、化合物
反応式
C(=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][C:10]=1OCCCN1CCOCC1.Br[CH:28]([CH3:30])[CH3:29]>CN(C)C=O>[CH3:7][O:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][C:10]=1[CH:28]([CH3:30])[CH3:29]参加物
5
反応条件
- 温度
- 85 °C
実験手順
8 g Potassium carbonate and 2.7 g 3-hydroxy-4-methoxybenzonitrile (for synthesis see Example 47) was dissolved in 25 mL dimethylformamide. 2.15 mL 2-Bromopropane was added and the mixture stirred at 85° C. for 3 h. The mixture was concentrated, diluted in ethyl acetate and washed with water (×2) and saturated sodium chloride solution, dried over magnesium sulfate and concentrated.
後処理
- concentrationThe mixture was concentrated
- additiondiluted in ethyl acetate
- washwashed with water (×2) and saturated sodium chloride solution
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-408c11bdf77744e591787b624b4fbbc5
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09187478B2
反応ノート
読み込み中…