4-Methylmorpholine → N'-(3,3-dimethylbutanoyl)-4-nitrobenzohydrazide

HRID 715828

反応式

HRID 715828 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([NH:10][NH2:11])=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].CN1CCOCC1.[CH3:21][C:22]([CH3:28])([CH3:27])[CH2:23][C:24](Cl)=[O:25]>ClCCl>[CH3:21][C:22]([CH3:28])([CH3:27])[CH2:23][C:24]([NH:11][NH:10][C:8](=[O:9])[C:7]1[CH:12]=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)=[O:25]

参加物

5

反応物 3

HCID 79724-MethylmorpholineHCID 815143,3-Dimethylbutanoyl chlorideHCID 3693744Benzoic acid, 4-nitro-, hydrazide

生成物 1

HCID 4628581N'-(3,3-dimethylbutanoyl)-4-nitrobenzohydrazide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A suspension of 4-nitrobenzohydrazide (0.500 g, 2.76 mmol), and 4-methylmorpholine (0.455 ml, 4.14 mmol) were stirred in dichloromethane (20 ml). 3,3-Dimethylbutanoyl chloride (0.422 ml, 3.04 mmol) was added and the reaction mixture was stirred for 2 hours. Normal phase chromatography of the crude reaction mixture gave the title compound.

後処理

  1. customNormal phase chromatography of the crude reaction mixture

出典と根拠

ORDレコード
ord-d3eefdfaafde46aa8c22e981e8c9e2e2
出典データセット
uspto-grants-2015_11
特許番号
US09187472B2

関連ノート

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