3,3,3-Trifluoro-1-propanol → 2-Chloro-5-(3,3,3-trifluoropropoxy)pyrimidine
反応式
[F:1][C:2]([F:7])([F:6])[CH2:3][CH2:4][OH:5].[Cl:8][C:9]1[N:14]=[CH:13][C:12](O)=[CH:11][N:10]=1>>[Cl:8][C:9]1[N:14]=[CH:13][C:12]([O:5][CH2:4][CH2:3][C:2]([F:7])([F:6])[F:1])=[CH:11][N:10]=1参加物
3
実験手順
Reactions similar to those of Reference Example 28 were performed except for using 3,3,3-trifluoro-1-propanol instead of 1-methyl-4-piperidinol, and from 100 mg (0.693 mmol) of 2-chloro-5-hydroxypyrimidine, 144 mg of the title compound as a colorless oil (yield: 92%).
出典と根拠
- ORDレコード
- ord-5bff100e3a8d4df7803e07f432ef442d
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09187450B2
反応ノート
読み込み中…