Methanol → HCID 89051975、化合物

HRID 716099ノート

反応式

HRID 716099 の反応式
C(N[CH:9]1[O:16][C@H:15]([CH2:17][OH:18])[C@@H:13]([OH:14])[C@H:11]([OH:12])[C@@H:10]1[NH:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)C1C=CC=CC=1.C[OH:28]>>[CH2:20]([NH:19][C@@H:10]([C@H:11]([C@@H:13]([C@@H:15]([CH2:17][OH:18])[OH:28])[OH:14])[OH:12])[CH:9]=[O:16])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

参加物

3

反応物 2

HCID 887MethanolHCID 70874206HCID 70874206、化合物

生成物 1

HCID 89051975HCID 89051975、化合物

反応条件

温度
40 °C

実験手順

From compound of example 1: to a suspension of N,N′-dibenzyl-1,2-diamino-1,2-dideoxy-D-mannopyranose (10 g) in methanol (30 ml) conc. HCl-solution (4 ml) was gradually added and the mixture was heated to 40° C. for 2-3 hours. The solvent was carefully evaporated, the residue was taken up in methanol and evaporated again 3-4 times. The resulting solid was suspended in ethanol and heated to reflux, the insoluble material was removed by hot filtration, and the filtrate was evaporated to dryness to yield the hydrochloride salt of N-benzyl-2-amino-2-deoxy-D-mannose.

後処理

  1. additionwas gradually added
  2. customThe solvent was carefully evaporated
  3. customevaporated again 3-4 times
  4. temperatureheated
  5. temperatureto reflux
  6. customthe insoluble material was removed by hot filtration
  7. customthe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-b6bcac4e9ccd44d08c937c3350bb6f44
出典データセット
uspto-grants-2015_11
特許番号
US09187513B2

反応ノート

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