Piperazine → N-methyl-4-(piperazin-1-yl)benzene-1-sulfonamide

HRID 716357

反応式

HRID 716357 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH3:12])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>O>[CH3:12][NH:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:3][CH:4]=1)(=[O:10])=[O:9]

参加物

4

反応物 2

HCID 4837PiperazineHCID 24400544-fluoro-N-methylbenzene-1-sulfonamide

生成物 1

HCID 23288834N-methyl-4-(piperazin-1-yl)benzene-1-sulfonamide収率 87%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
120 °C

実験手順

4-fluoro-N-methylbenzenesulfonamide (189 mg, 0.999 mmol) and piperazine (430 mg, 4.99 mmol) were combined and the reaction mixture was stirred at 120° C. for 2 h. It was diluted with water (5 mL) and stirred until a fine suspension resulted. The precipitate was filtered, washed with water (5×3 mL) and dried in vacuum to afford N-methyl-4-(piperazin-1-yl)benzenesulfonamide (222 mg, 0.869 mmol, 87% yield) as a white solid. ESI-MS: m/z 256 (M+H)+.

後処理

  1. stirringstirred until a fine suspension
  2. customresulted
  3. filtrationThe precipitate was filtered
  4. washwashed with water (5×3 mL)
  5. customdried in vacuum

出典と根拠

ORDレコード
ord-40112ecbc1fd42b0a76eb6c9c614a621
出典データセット
uspto-grants-2015_11
特許番号
US09187497B2

関連ノート

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