Acetic Anhydride → Bis-(maleimidoethoxy) ethane

HRID 716665

反応式

HRID 716665 の反応式
[C:1]1(=[O:7])O[C:4](=[O:5])[CH:3]=[CH:2]1.[CH2:8]([CH2:13][O:14][CH2:15][CH2:16][NH2:17])[O:9][CH2:10][CH2:11][NH2:12].[C:18]([O-:21])(=O)[CH3:19].[Na+].[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[CH2:13]([O:14][CH2:15][CH2:16][N:17]1[C:1](=[O:7])[CH:2]=[CH:3][C:4]1=[O:5])[CH2:8][O:9][CH2:10][CH2:11][N:12]1[C:18](=[O:21])[CH:19]=[CH:24][C:23]1=[O:25]

参加物

5

反応物 4

HCID 7918Acetic AnhydrideHCID 7923Maleic AnhydrideHCID 70248Bis-AminoethylglycolHCID 517045Sodium Acetate

生成物 1

HCID 3690297Bis-(maleimidoethoxy) ethane

実験手順

The general procedure was carried out using maleic anhydride (13.23 g, 135 mmol), 2,2′-(ethylenedioxy)bis(ethylamine) (10.0 g, 67.5 mmol), sodium acetate (1.11 g, 13.5 mmol), and acetic anhydride (15.15 g, 148 mmol). The resulting compound was purified by column chromatography (95:5 DCM:EtOAc), and the product obtained as a white solid (4.5 g/22%).

後処理

  1. customThe resulting compound was purified by column chromatography (95:5 DCM:EtOAc)
  2. customthe product obtained as a white solid (4.5 g/22%)

出典と根拠

ORDレコード
ord-e61e1364dca24f1d9c1dac17ebcc359c
出典データセット
uspto-grants-2015_11
特許番号
US09193139B2

関連ノート

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