Hydrochloric Acid → Cloquintocet
反応式
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]([O:16]C(C)CCCCC)=[O:15])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.Cl>O>[CH:5]1[CH:6]=[N:7][C:8]2[C:3](=[C:2]([Cl:1])[CH:11]=[CH:10][C:9]=2[O:12][CH2:13][C:14]([OH:16])=[O:15])[CH:4]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
A suspension of 70.70 g of cloquintocet-mexyl (96.9% strength) in 205 g of demineralised water was stirred at 100° C. in a 1 L jacketed glass vessel. 27.5 g of aqueous hydrochloric acid [32%] was slowly added, and the reaction mixture was stirred under reflux for 6 hours. The biphasic solution was then cooled down to 20° C. over 4 hours and the resulting suspension was filtered and the solid was wash with 2×50 mL of demineralised water and dried. Cloquintocet acid hydrochloride (35.55 g) was isolated as a light brown solid.