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2-Chlorophenol → 4-Chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chlorophenol | HCID 7245 | — |
| 反応物 | Fluoxastrobin | HCID 11048796 | — |
| 反応物 | 4,6-Dichloro-5-fluoropyrimidine | HCID 11286675 | — |
| 生成物 | 4-Chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine | HCID 11230678 | — |
反応手順
Fluoxastrobin may further be prepared as described in Scheme 3. Particularly, 4,6-dichloro-5-fluoropyrimidine (5) is reacted with 2-chlorophenol in an appropriate solvent and in the presence of a suitable base to give intermediate 4-chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine (17) which is further reacted with (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime (13) to give fluoxastrobin.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09193698B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-84fc7b85c1d84a1f9a41fab65b5c04d4 |
| 出典メモ | uspto-grants-2015_11 |