Sulfuric Acid → Coumaranone

HRID 716728

反応式

HRID 716728 の反応式
C([O:4][C:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[O:7][CH:6]=1)(=O)C.OS(O)(=O)=O>CO>[O:7]1[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:5](=[O:4])[CH2:6]1

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 27696211-Benzofuran-3-yl acetate

生成物 1

HCID 23556Coumaranone収率 83%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of benzofuran-3-yl acetate (8) (100 g, 1.42 mol) in methanol (350 mL) was added diluted (7.5%) H2SO4 (500 mL) at ambient temperature followed by heating to reflux for 1-3 h. The progress of the reaction was monitored by HPLC analysis. Upon completion of the reaction, the reaction mixture was cooled, filtered, and the slurry was washed with water, and vacuum dried to obtain the product meeting the desired specifications. Yield—83-100%.

後処理

  1. temperatureby heating
  2. temperatureto reflux for 1-3 h
  3. customUpon completion of the reaction
  4. temperaturethe reaction mixture was cooled
  5. filtrationfiltered
  6. washthe slurry was washed with water, and vacuum
  7. customdried
  8. customto obtain the product

出典と根拠

ORDレコード
ord-69ad0f572a2c40928d1126551b4af5f7
出典データセット
uspto-grants-2015_11
特許番号
US09193698B2

関連ノート

読み込み中…