Phenethylamine → Formamide, N-(2-phenylethyl)-

HRID 716953

反応式

HRID 716953 の反応式
[C:1]1([CH2:7][CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:10](OCC)=[O:11]>>[CH2:8]([NH:9][CH:10]=[O:11])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

3

反応物 2

HCID 1001PhenethylamineHCID 8025Ethyl formate

生成物 1

HCID 140995Formamide, N-(2-phenylethyl)-

反応条件

温度
50 °C

実験手順

Into a 100-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed 2-phenylethanamine (1.9 g, 15.70 mmol, 1.00 equiv). This was followed by the addition of ethyl formate (5 g, 67.57 mmol, 4.30 equiv) dropwise with stiffing. The resulting solution was stirred overnight at 50° C. The resulting solution was concentrated under vacuum. The residue was applied onto a silica gel column with dichloromethane/methanol (70:1). This resulted in 2.27 g (97%) of N-phenethylformamide as yellow oil.

後処理

  1. customInto a 100-mL 3-necked round-bottom flask purged
  2. temperaturemaintained with an inert atmosphere of nitrogen
  3. concentrationThe resulting solution was concentrated under vacuum
  4. customThis resulted in 2.27 g (97%) of N-phenethylformamide as yellow oil

出典と根拠

ORDレコード
ord-3297cd83d6744d5c9fce381b2a37e689
出典データセット
uspto-grants-2015_11
特許番号
US09193693B2

関連ノート

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