Epichlorohydrin → 1-[2-(4-Bromophenyl)-2-propyl]azetidin-3-ol
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH2:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[CH2:12]([CH:14]1[O:16][CH2:15]1)Cl>CCO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:11]2[CH2:15][CH:14]([OH:16])[CH2:12]2)([CH3:9])[CH3:10])=[CH:6][CH:7]=1参加物
4
実験手順
1-(4-Bromophenyl)-1-methyl-ethylamine (1 g, 4.67 mmol) and epichlorohydrin (439 μl, 5.6 mmol) in EtOH (15 mL) were heated at 70° C. for 18 h. The reaction mixture was concentrated in vacuo and purified by reverse phase preparative HPLC-MS to obtain 1-[1-(4-bromo-phenyl)-1-methyl-ethyl]-azetidin-3-ol as a white solid (489 mg, 38%).
後処理
- concentrationThe reaction mixture was concentrated in vacuo
- custompurified by reverse phase preparative HPLC-MS
出典と根拠
- ORDレコード
- ord-80d4f3e7eeb847a1a82650c798df9ac5
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09193689B2
反応ノート
読み込み中…