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6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride → 2-[[2-(3,4,5-Trimethoxyphenyl)quinazolin-4-yl]carbonyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride | HCID 2920335 | — |
| 反応物 | 2-(3,4,5-Trimethoxyphenyl)quinazoline-4-carboxylic acid | HCID 90410314 | — |
| 生成物 | 2-[[2-(3,4,5-Trimethoxyphenyl)quinazolin-4-yl]carbonyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline | HCID 86267574 | 57.1% |
反応手順
Reaction of 2-(3,4,5-trimethoxyphenyl)quinazoline-4-carboxylic acid with 6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride gave compound 91 (57.1% yield). 1H NMR (300 MHz, DMSO-d6) δ 2.86 and 3.03 (2t, 2H), 3.51 and 4.04 (2t, 2H), 3.72-3.78 (m, 6H), 3.87 and 3.92 (2s, 6H), 4.43 and 4.94 (2s, 2H), 6.65-7.27 (m, 3H), 7.68-8.18 (m, 6H); MS (ESI) m/z 486 ([M+H]+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09193707B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-d9dedcaf16864eed89958f096f9cc815 |
| 出典メモ | uspto-grants-2015_11 |