2,2-Dimethyl-1-(pyrazin-2-yl)cyclopropanol → 2,2-Dimethyl-1-(piperazin-2-yl)cyclopropanol
反応式
[CH3:1][C:2]1([CH3:12])[CH2:4][C:3]1([C:6]1[CH:11]=[N:10][CH:9]=[CH:8][N:7]=1)[OH:5]>CO.[Pt]=O>[CH3:1][C:2]1([CH3:12])[CH2:4][C:3]1([CH:6]1[CH2:11][NH:10][CH2:9][CH2:8][NH:7]1)[OH:5]参加物
4
実験手順
A suspension of 2,2-dimethyl-1-(pyrazin-2-yl)cyclopropanol (1 g, 6 mmol) and platinum oxide (150 mg; 0.66 mmol) in methanol (15 ml) was shaken under a 60 psi H2 pressure using a PARR hydrogenator for 24 hours. The suspension was filtered over a celite pad and the filtrate was concentrated under reduced pressure to afford the title compound as a beige oil (1 g, 95%). 1H NMR (CD3OD) 0.90 (2H, s), 1.20-1.25 (6H, m), 2.45-2.50 (1H, m), 2.60-3.00 (5H, m), 3.30-3.40 (1H, m).
後処理
- customfor 24 hours
- filtrationThe suspension was filtered over a celite pad
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-84d195e2d70d41e8bd8151666d219346
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09193722B2
反応ノート
読み込み中…