2,2-dimethyl-N-(4-octylphenyl)-1,3-dioxan-5-amine → 2-(4-Octylphenylamino)propane-1,3-diol

HRID 717617ノート

反応式

HRID 717617 の反応式
CC1(C)[O:7][CH2:6][CH:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:11][CH:10]=2)[CH2:4][O:3]1>CO>[CH2:15]([C:12]1[CH:11]=[CH:10][C:9]([NH:8][CH:5]([CH2:6][OH:7])[CH2:4][OH:3])=[CH:14][CH:13]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

参加物

3

反応物 1

HCID 666148752,2-dimethyl-N-(4-octylphenyl)-1,3-dioxan-5-amine

生成物 1

HCID 461992032-(4-Octylphenylamino)propane-1,3-diol収率 115.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of the product of Step A (0.1 g; 0.31 mmol) in MeOH (1 ml) Me3SiCl (0.5 ml) was added at room temperature. After stirring for 1 h, the mixture was evaporated to dryness under reduced pressure to give a hydrochloride salt of the title compound (0.1 g; 100%) as a colourless solid. 1H-NMR (CDCl3) 10.66 (bs, 2H); 7.53 (d, 2H, J=7.98 Hz); 7.18 (d, 2H, J=7.98 Hz); 4.82 (broad s, 2H); 3.98 (broad m, 4H); 3.51 (broad m, 1H); 2.58 (t, 2H, J=7.68 Hz); 1.56 (m, 2H); 1.43 (s, 3H); 1.27 (m, 10H); 0.86 (t, 3H, J=6.96 Hz).

後処理

  1. customthe mixture was evaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-5fe0ffb29f80444a8d201dbf65f3271e
出典データセット
uspto-grants-2015_11
特許番号
US09193716B2

反応ノート

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