5-Methylindoline → 5-Methyl-1-nitrosoindoline
反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH2:6][CH2:5]2.[N:11]([O-])=[O:12].[Na+]>Cl.O>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([N:11]=[O:12])[CH2:6][CH2:5]2参加物
5
反応条件
- 温度
- 0 °C
実験手順
5-Methylindoline (1.0 g, 7.5 mmol) was stirred in 3N HCl (20 mL) at 0° C. Sodium nitrite (0.621 g, 9.0 mmol) in water (2 mL) was added dropwise and the mixture was stirred at 0° C. for 5 min. followed by RT for 20 min. The reaction mixture was extracted with DCM (500 mL), and the organic layer was dried over sodium sulfate and concentrated under vacuum to obtain 1.2 g of 5-methyl-1-nitrosoindoline.
後処理
- waitfollowed by RT for 20 min
- extractionThe reaction mixture was extracted with DCM (500 mL)
- dry with materialthe organic layer was dried over sodium sulfate
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-87962a4fe92a449ba21dd06f782d09e1
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09193728B2
反応ノート
読み込み中…