Trimethyl orthobeznoate → HCID 34176367、化合物

反応式

[Cl:1][C:2]1[C:7]([NH:8][NH2:9])=[N:6][CH:5]=[CH:4][N:3]=1.CO[C:12](OC)(OC)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[Cl:1][C:2]1[C:7]2[N:6]([C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:9][N:8]=2)[CH:5]=[CH:4][N:3]=1

参加物

反応物 2

HCID 69720Trimethyl orthobeznoate

HCID 3214302-Chloro-3-hydrazinopyrazine

生成物 1

HCID 34176367HCID 34176367、化合物収率 105.8%

反応条件

温度: 120 °C

実験手順

Title compound 471 (0.8 g, 5.53 mmol) and Trimethyl orthobenzoate (5 mL, 29.1 mmol) were combined and the reaction mixture was stirred at 120° C. for 3 h. The mixture was cooled to room temperature and the solid was filtered and washed with hexanes to afford title compound 472 (1.35 g, 100%) as a beige solid. MS (m/z): 231.1 (M+H)

後処理

temperatureThe mixture was cooled to room temperature
filtrationthe solid was filtered
washwashed with hexanes

出典と根拠

ORDレコード: ord-a201afb3b8c94afba25c575de74590ba
出典データセット: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09193749B2

反応ノート

読み込み中…

参加物