Hydrochloric Acid → Ethyl 2-methylpropanimidate--hydrogen chloride (1/1)

HRID 718150ノート

反応式

HRID 718150 の反応式
[C:1](#[N:5])[CH:2]([CH3:4])[CH3:3].[ClH:6].[CH2:7]([OH:9])[CH3:8]>>[ClH:6].[C:1](=[NH:5])([O:9][CH2:7][CH3:8])[CH:2]([CH3:4])[CH3:3]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 6559Isobutyronitrile

生成物 1

HCID 12816252Ethyl 2-methylpropanimidate--hydrogen chloride (1/1)収率 82%

実験手順

Isobutyronitrile (1 g, 14.5 mmol) was dissolved in anhydrous ethanol (30 mL) under an atmosphere of Ar. The solution was cooled to 0° C., saturated with HCl gas, stirred for 6 h, allowed to warm to RT, and stirred for 6 h. The solvent was removed in vacuo to afford ethyl isobutyrimidate hydrochloride (1.8 g, 82%) as a colorless solid. 1H NMR (400 MHz, DMSO-d6): δ 11.78 (br s, 1H), 11.05 (br s, 1H), 4.40 (q, J=7.0 Hz, 2H), 2.93-2.92 (m, 1H), 1.33 (t, J=7.0 Hz, 3H), 1.16 (d, J=6.9 Hz, 6H).

後処理

  1. stirringstirred for 6 h
  2. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-b848dd8932684118b5196eeb2c474870
出典データセット
uspto-grants-2015_11
特許番号
US09193719B2

反応ノート

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