化工社化工社 化学情報印刷レポート · 研究参考用
4,4'-Diazenediyldianiline → N-Boc-pyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,4'-Diazenediyldianiline | HCID 10855 | — |
| 反応物 | 1(2H)-Quinolinecarboxylic acid, ethyl ester | HCID 27813 | — |
| 反応物 | 1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid | HCID 268472 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-Boc-pyrrolidine | HCID 643455 | 166.6% |
反応手順
4-(4-aminophenylazo)-phenylamine (3.02 g) and pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (7.00 g) were dissolved in DCM (90 mL), and 1-ethoxycarbonyl-1,2-dihydroquinoline (8.45 g) was added. The reaction mixture was stirred at ambient temperature for 19 hours and evaporated under vacuum. Oil was dissolved in ethyl acetate, forming a precipitate, which was collected by vacuum filtration and dried under vacuum, giving 2-(4-{4-[(1-carboxylic acid tert-butyl ester-pyrrolidine-2-carbonyl)-amino]-phenylazo}-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (9.28 g) as a brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822430B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-004b028f6ee8484e9f6058adb3c2a4da |
| 出典メモ | uspto-grants-2014_09 |