Isocyanic acid, p-methoxybenzyl- → 4-(5-Amino-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-7-yl)-n-(4-methoxybenzyl)piperazine-1-carboxamide

HRID 718283

反応式

HRID 718283 の反応式
[N:1]1([C:7]2[C:8]3[N:16]=[C:15]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[S:14][C:9]=3[N:10]=[C:11]([NH2:13])[N:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH3:23][O:24][C:25]1[CH:34]=[CH:33][C:28]([CH2:29][N:30]=[C:31]=[O:32])=[CH:27][CH:26]=1>>[NH2:13][C:11]1[N:12]=[C:7]([N:1]2[CH2:6][CH2:5][N:4]([C:31]([NH:30][CH2:29][C:28]3[CH:33]=[CH:34][C:25]([O:24][CH3:23])=[CH:26][CH:27]=3)=[O:32])[CH2:3][CH2:2]2)[C:8]2[N:16]=[C:15]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[S:14][C:9]=2[N:10]=1

参加物

3

反応物 2

HCID 187910Isocyanic acid, p-methoxybenzyl-HCID 509420567-(Piperazin-1-yl)-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-5-amine

生成物 1

HCID 667586274-(5-Amino-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-7-yl)-n-(4-methoxybenzyl)piperazine-1-carboxamide収率 40%

実験手順

This compound was prepared from 7-(piperazin-1-yl)-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-5-amine using 4-methoxybenzyl isocyanate in a yield of 40%, according to the procedure for the synthesis of example 42.

後処理

  1. customaccording to the procedure for the synthesis of example 42

出典と根拠

ORDレコード
ord-e32f2e7bf5aa41039490bba2ed98f4aa
出典データセット
uspto-grants-2015_11
特許番号
US09193741B2

関連ノート

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