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Lilial → 1-tert-Butyl-4-(5-(4-methoxyphenyl)-2-methylpent-3-enyl)benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lilial | HCID 228987 | — |
| 反応物 | p-Methoxyphenethyltriphenylphosphonium bromide | HCID 85891800 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 生成物 | 1-tert-Butyl-4-(5-(4-methoxyphenyl)-2-methylpent-3-enyl)benzene | HCID 86702774 | 51.1% |
反応手順
Starting from p-methoxyphenethyltriphenylphosphonium bromide (3.10 g, 6.49 mmol, 1.0 equiv.), n-BuLi (1.6 M in hexanes, 4.1 mL, 6.49 mmol, 1.0 equiv.) and 3-(4-tert-butylphenyl)-2-methylpropanal (1.99 g, 9.74 mmol, 1.5 equiv.), 1.07 g (44%) of the title compound as a light yellow oil was obtained after purification by flash chromatography on SiO2 (cyclohexane/EtOAc 997:3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09193935B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-d4384ce46d1e4ac9bd0eabb3e58f8070 |
| 出典メモ | uspto-grants-2015_11 |