化工社化工社 化学情報印刷レポート · 研究参考用
Lilial → 1-tert-Butyl-4-(2-methyl-5-p-tolylpent-3-enyl)benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lilial | HCID 228987 | — |
| 反応物 | (2-(P-Tolyl)ethyl)triphenylphosphonium bromide | HCID 20466351 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 生成物 | 1-tert-Butyl-4-(2-methyl-5-p-tolylpent-3-enyl)benzene | HCID 86702777 | 42% |
反応手順
Starting from p-methylphenethyltriphenylphosphonium bromide (5.04 g, 9.91 mmol, 1.0 equiv.), n-BuLi (1.6 M in hexanes, 6.2 mL, 9.91 mmol, 1.0 equiv.) and 3-(4-tert-butylphenyl)-2-methylpropanal (3.04 g, 14.9 mmol, 1.5 equiv.), 1.26 g (42%) of the title compound as a light yellow oil was obtained after purification by flash chromatography on SiO2 (cyclohexane/EtOAc 997:3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09193935B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-9389887afbbb428a82bf740cd0d8d615 |
| 出典メモ | uspto-grants-2015_11 |