反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.[N+](=[CH2:16])=[N-]>C(Cl)Cl.CC([O-])=O.CC([O-])=O.[Pd+2]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]2[CH2:16][C@@H:9]2[C:10]([O:12][CH3:13])=[O:11])=[CH:6][CH:7]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a mixture of compound 66c (1.50 g, 6.22 mmol) and Pd(OAc)2 (90 mg, 0.40 mmol) in DCM (20 mL) was added an ethereal solution of compound 66b (200 mL). After stirring for 10 min at 0° C., the reaction mixture was concentrated under reduced pressure to yield a residue, which was subjected to flash column chromatography on silica gel (10% EtOAc/petroleum ether) to afford compound 66d as colorless oil. Mass Spectrum (GCMS, ESI pos.): Calcd. for C11H11BrO2: 254.0 (M). found: 254.0.
後処理
- concentrationthe reaction mixture was concentrated under reduced pressure
- customto yield a residue, which
出典と根拠
- ORDレコード
- ord-899384643d394dd09ce1f98e8bfb819a
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09193736B2
関連ノート
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