Ethanol → HCID 15134190、化合物

HRID 718690ノート

反応式

HRID 718690 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:8]([C:12]([OH:14])=[O:13])=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.OS(O)(=O)=O.[CH3:20][CH2:21]O>C(Cl)Cl>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:8]([C:12]([O:14][CH2:20][CH3:21])=[O:13])=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1

参加物

5

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 3199762-Methyl-5-quinolinecarboxylic acid

生成物 1

HCID 15134190HCID 15134190、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a slurry of compound 73a (3.1 g, 16 mmol) in EtOH (50 mL) was added concentrated H2SO4 (1.0 mL) and the resultant slurry was refluxed overnight. The homogeneous solution was cooled, diluted with DCM (300 mL), washed with 1N NaOH (1×100 mL), dried (Na2SO4), and concentrated in vacuo to give compound 73b as an off-white solid. Mass spectrum (LCMS, ESI pos.) Calcd. For C13H13NO2: 216.2 (M+H). found 216.2.

後処理

  1. temperaturethe resultant slurry was refluxed overnight
  2. temperatureThe homogeneous solution was cooled
  3. washwashed with 1N NaOH (1×100 mL)
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-fddecac2ec004fb285028b74eb0ac7d7
出典データセット
uspto-grants-2015_11
特許番号
US09193736B2

反応ノート

読み込み中…