反応式
[CH3:1][O:2][C:3](=[O:53])[NH:4][CH:5]([C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH:12]1[C:16]1[NH:17][C:18]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][C:30]([C:33]4[NH:34][C:35]([CH:38]([NH:41][C:42](=[O:52])[CH:43]([NH:47][C:48]([O:50][CH3:51])=[O:49])[CH:44]([CH3:46])[CH3:45])[CH2:39]O)=[N:36][CH:37]=4)=[CH:29][CH:28]=3)=[CH:23][CH:22]=2)=[CH:19][N:20]=1)=[O:10])[CH:6]([CH3:8])[CH3:7].O1CCNC1.[CH:59]1([CH:62]2CN[C@H](C(O)=O)C2)[CH2:61][CH2:60]1.Cl>O1CCOCC1>[CH3:51][O:50][C:48](=[O:49])[NH:47][CH:43]([C:42]([N:41]1[CH:38]([C:35]2[NH:34][C:33]([C:30]3[CH:29]=[CH:28][C:27]([C:24]4[CH:23]=[CH:22][C:21]([C:18]5[NH:17][C:16]([CH:12]6[CH2:13][CH2:14][CH2:15][N:11]6[C:9](=[O:10])[CH:5]([NH:4][C:3]([O:2][CH3:1])=[O:53])[CH:6]([CH3:8])[CH3:7])=[N:20][CH:19]=5)=[CH:26][CH:25]=4)=[CH:32][CH:31]=3)=[CH:37][N:36]=2)[CH2:39][C:59]2([CH2:61][CH2:60]2)[CH2:62]1)=[O:52])[CH:44]([CH3:46])[CH3:45]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
was prepared in a similar fashion to (1-{2-[5-(4′-{2-[2-Hydroxy-1-(2-methoxycarbonylamino-3-methyl-butyrylamino)-ethyl]-3H-imidazol-4-yl}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester, replacing the oxazolidine derived carboxylic acid with the corresponding 4-cyclopropyl-proline derivative and using HCl in dioxane for the Boc deprotection.
出典と根拠
- ORDレコード
- ord-40489271826541b6b8c271af9c74db81
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08822430B2
関連ノート
読み込み中…