Benzyl isocyanate → ethyl 2-(1-Methyl-2-(benzylcarbamoyl)hydrazinyl)acetate

反応式

[CH3:1][N:2]([CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])[NH2:3].[CH2:10]([N:17]=[C:18]=[O:19])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH3:1][N:2]([CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])[NH:3][C:18](=[O:19])[NH:17][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

反応物 2

HCID 76639Benzyl isocyanate

HCID 20288078Ethyl 2-(1-methylhydrazinyl)acetate

生成物 1

HCID 66977957ethyl 2-(1-Methyl-2-(benzylcarbamoyl)hydrazinyl)acetate収率 76%

実験手順

According to the procedure described in the synthesis method of Compound V-1 with the modification that the reaction was carried out overnight, ethyl 2-(1-methylhydrazinyl)acetate (Compound XV-2) 10 ml (76 mmol) was reacted with benzyl isocyanate 11.1 g (83.3 mmol) to obtain the title compound 15.2 g (76%).

後処理

customdescribed in the synthesis method of Compound V-1 with the modification that the reaction

出典と根拠

ORDレコード: ord-d3af802979d0478eac5f9c8d983cf712
出典データセット: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09193734B2

反応ノート

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