Acetyl chloride → 4-Methoxy-benzo[a]phenazine-11-carboxylic Acid Methyl Ester
反応式
[C:1](Cl)(=O)C.[CH3:5][O:6][C:7]1[C:12]2=[CH:13][CH:14]=[C:15]3[C:24]([N:23]=[C:22]4[C:17]([CH:18]=[CH:19][CH:20]=[C:21]4[C:25]([OH:27])=[O:26])=[N:16]3)=[C:11]2[CH:10]=[CH:9][CH:8]=1>CO>[CH3:1][O:26][C:25]([C:21]1[C:22]2[C:17](=[N:16][C:15]3[C:24]([N:23]=2)=[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([O:6][CH3:5])[C:12]2=[CH:13][CH:14]=3)[CH:18]=[CH:19][CH:20]=1)=[O:27]参加物
4
実験手順
Acetyl chloride (4.6 mL) was added dropwise to a suspension of 4-methoxy-benzo[a]phenazine-11-carboxylic acid (II.1, see Reference Example 1A, 4.9 g) in methanol (50 mL). The mixture was heated to reflux for 4 hours. The volatiles were then removed in vacuo to yield the title compound as a dark solid (quantitative yield).