Benzo[a]phenazine-11-carboxylic acid → Benzo[a]phenazine-11-carboxylic Acid Methyl Ester

HRID 719185

反応式

HRID 719185 の反応式
[CH:1]1[C:6]2=[C:7]3[C:16](=[CH:17][CH:18]=[C:5]2[CH:4]=[CH:3][CH:2]=1)[N:15]=[C:14]1[C:9]([C:10]([C:19]([OH:21])=[O:20])=[CH:11][CH:12]=[CH:13]1)=[N:8]3.[CH:22]1C2=C3C(=CC=C2C=CC=1)N=C1C(C=CC=C1C(O)=O)=N3>CO.C(Cl)(=O)C>[CH3:22][O:20][C:19]([C:10]1[C:9]2[C:14](=[N:15][C:16]3[C:7]([N:8]=2)=[C:6]2[CH:1]=[CH:2][CH:3]=[CH:4][C:5]2=[CH:18][CH:17]=3)[CH:13]=[CH:12][CH:11]=1)=[O:21]

参加物

5

反応物 2

HCID 13792239Benzo[a]phenazine-11-carboxylic acidHCID 13792240Benzo[a]phenazine-8-carboxylic acid

生成物 1

HCID 69596869Benzo[a]phenazine-11-carboxylic Acid Methyl Ester

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6367Acetyl chloride溶媒

実験手順

The mixture of benzo[a]phenazine-11-carboxylic acid (II.20) and benzo[a]phenazine-8-carboxylic acid (885 mg), prepared as described in Reference Example 1L above, was heated to reflux in a mixture of methanol (40 mL) and acetyl chloride (920 μL) for 90 minutes. The reaction mixture was then cooled slowly to yield the title compound as a single isomer which was collected by filtration (377 mg).

後処理

  1. customprepared
  2. temperaturewas heated
  3. temperatureThe reaction mixture was then cooled slowly

出典と根拠

ORDレコード
ord-e7ec6d73fdcd4b9e95de8ba8e87f0f5e
出典データセット
uspto-grants-2006_11
特許番号
US07132419B2

関連ノート

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