Benzoyl chloride → HCID 178434586、化合物

反応式

[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][C:11]1[C:12]([CH3:25])=[N:13][NH:14][C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([N:22]([CH3:24])[CH3:23])[CH:17]=1>>[CH3:24][N:22]([CH3:23])[C:18]1[CH:17]=[C:16]([C:15]2[NH:14][N:13]=[C:12]([CH3:25])[C:11]=2[NH:10][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:21]=[CH:20][CH:19]=1

参加物

反応物 2

HCID 7412Benzoyl chloride

HCID 1784345853-[3-(Dimethylamino)phenyl]-5-methyl-1H-pyrazol-4-amine

生成物 1

HCID 178434586HCID 178434586、化合物

実験手順

The preparation was carried out as in Example 22A, using 460 mg of benzoyl chloride and 700 mg of 4-amino-5-(3-dimethylamino-phenyl)-3-methylpyrazole, except the reaction mixture was stirred for 16 h and the residue was purified by MPLC (ethyl acetate as eluant) to give the title compound as a tan solid.

後処理

customthe residue was purified by MPLC (ethyl acetate as eluant)

出典と根拠

ORDレコード: ord-db322e4b1f3d4434ad7439abe93c5491
出典データセット: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07132428B2

反応ノート

読み込み中…

参加物