2-Mercaptoethanol → 3'-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester

HRID 719710ノート

反応式

HRID 719710 の反応式
C(OC(C1C=C(C2C=CC(C[S:19][CH2:20][CH2:21][OH:22])=CC=2)C=CC=1)=O)C.[CH2:23]([O:25][C:26]([C:28]1[CH:33]=[CH:32][C:31]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([CH2:40]Br)[CH:35]=2)=[CH:30][CH:29]=1)=[O:27])[CH3:24].SCCO.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:23]([O:25][C:26]([C:28]1[CH:33]=[CH:32][C:31]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([CH2:40][S:19][CH2:20][CH2:21][OH:22])[CH:35]=2)=[CH:30][CH:29]=1)=[O:27])[CH3:24]

参加物

6

反応物 4

HCID 15672-MercaptoethanolHCID 11430Potassium CarbonateHCID 586105794'-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl esterHCID 586105873'-Bromomethyl-biphenyl-4-carboxylic acid ethyl ester

生成物 1

HCID 586105983'-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

3′-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester was synthesized as described for 4′-(2-hydroxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl ester. 3′-Bromomethyl-biphenyl-4-carboxylic acid ethyl ester (4.98 g, 15.6 mmol, 1 eq) in anhydrous DMF was treated with 2-mercaptoethanol (2.44 g, 31.20 mmol, 2 eq.) and potassium carbonate (6.47 g, 46.80 mmol, 3 eq.). When complete, the reaction was worked up as described leaving a yellow oil.

後処理

  1. customas described leaving a yellow oil

出典と根拠

ORDレコード
ord-f3ea096d400641448c348262cbcd3c2a
出典データセット
uspto-grants-2006_11
特許番号
US07132456B2

反応ノート

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