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Azobisisobutyronitrile → Ethyl 2'-bromomethyl-2-biphenylcarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Azobisisobutyronitrile | HCID 6547 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | [1,1'-Biphenyl]-2-carboxylic acid, 2'-methyl-, ethyl ester | HCID 18325921 | — |
| 反応物 | 4'-Bromomethyl-biphenyl-3-carboxylic acid ethyl ester | HCID 21464255 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | Ethyl 2'-bromomethyl-2-biphenylcarboxylate | HCID 58610597 | — |
反応手順
2′-Bromomethyl-biphenyl-2-carboxylic acid ethyl ester was synthesized as described for 4′-bromomethyl-biphenyl-3-carboxylic acid ethyl ester. 2′-Methyl-biphenyl-2-carboxylic acid ethyl ester (10.35 g, 43.07 mmol, 1 eq.) in carbon tetrachloride was treated with N-bromosuccinimide (9.20 g, 51.68 mmol, 1.2 eq.) and 2,2′-azobisisobutyronitrile (0.35 g, 2.15 mmol, 5 mol %). When complete, the reaction was worked up as described leaving an orange oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07132456B2 |
| 出典データセット | uspto-grants-2006_11 |
| ORD ID | ord-bfe0762c9053428d9e2d601f66ec8932 |
| 出典メモ | uspto-grants-2006_11 |