Toluene → HCID 86595355、化合物

HRID 719739ノート

反応式

HRID 719739 の反応式
[Cl:1][CH2:2][CH:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1.C[C:18]1[NH:19][CH:20]=[CH:21][N:22]=1.[C:23]1(C)C=CC=CC=1>>[Cl-:1].[CH3:23][N+:22]1[CH:21]=[CH:20][N:19]([CH2:2][CH:3]2[CH2:7][CH2:6][CH2:5][N:4]2[C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=2)[CH:18]=1

参加物

4

反応物 3

HCID 1140TolueneHCID 127492-MethylimidazoleHCID 21901780HCID 21901780、化合物

生成物 1

HCID 86595355HCID 86595355、化合物

実験手順

16.8 g (0.07 mol) of 2-chloromethyl-1-(4-nitrophenyl)pyrrolidine (1), 17.2 g (0.21 mol) of methylimidazole and 70 ml of toluene were refluxed for 9 hours. The solvent was evaporated off and the product was recrystallized from isopropanol and then dried under vacuum. 3 g of yellow crystals (2) were obtained.

後処理

  1. customThe solvent was evaporated off
  2. customthe product was recrystallized from isopropanol
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-638fa5ddce4e489ea4fa24a0c49d2e8e
出典データセット
uspto-grants-2006_11
特許番号
US07132543B2

反応ノート

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