Benzenesulfinic acid → Furan, tetrahydro-2-(phenylsulfonyl)-
反応式
[O:1]1[CH:5]=[CH:4][CH2:3][CH2:2]1.[C:6]1([S:12]([OH:14])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(Cl)Cl>[C:6]1([S:12]([CH:5]2[CH2:4][CH2:3][CH2:2][O:1]2)(=[O:14])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1参加物
4
反応条件
- 温度
- 25 °C
実験手順
A mixture of 2,3-dihydrofuran (1.40 g, 19.97 mmol) and benzene sulfinic acid (3.12 g, 21.97 mmol) in methylene chloride (80 mL) was stirred at 25° C. for 2 h. The reaction was then transferred to a separatory funnel and washed with a saturated aqueous sodium carbonate solution (15 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo. The resulting solid was then recrystallized using diethyl ether/petroleum ether to afford 2-benzenesulfonyl-tetrahydro-furan as a white solid: mp 55.9–56.8° C.
後処理
- customThe reaction was then transferred to a separatory funnel
- washwashed with a saturated aqueous sodium carbonate solution (15 mL)
- dry with materialThe organic layer was dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe resulting solid was then recrystallized
出典と根拠
- ORDレコード
- ord-0c4b9590061042fba617b09dd9b2656b
- 出典データセット
- uspto-grants-2006_11
- 特許番号
- US07132425B2
反応ノート
読み込み中…