Hydrochloric Acid → (2r)-2-Amino-3-naphthalen-2-yl-n-(6-oxo-2-phenyl-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)propanamide hydrochloride

HRID 720142

反応式

HRID 720142 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C@@H:12]([NH:36]C(=O)OC(C)(C)C)[C:13](=[O:35])[NH:14][C:15]1[CH:16]=[C:17]2[C:33](=[O:34])[NH:32][N:31]=[CH:30][C:19]3=[C:20]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[NH:21][C:22]([CH:23]=1)=[C:18]23.[ClH:44]>O1CCOCC1>[ClH:44].[NH2:36][C@H:12]([CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[C:13]([NH:14][C:15]1[CH:16]=[C:17]2[C:33](=[O:34])[NH:32][N:31]=[CH:30][C:19]3=[C:20]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[NH:21][C:22]([CH:23]=1)=[C:18]23)=[O:35]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 1361816471,1-Dimethylethyl (1R)-1-(naphthalen-2-ylmethyl)-2-oxo-2-[(6-oxo-2-phenyl-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)amino]ethylcarbamate

生成物 1

HCID 136401960(2r)-2-Amino-3-naphthalen-2-yl-n-(6-oxo-2-phenyl-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)propanamide hydrochloride収率 99%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Preparation of example 176 from the title compound of Example 154 (59 mg, 0.103 mmol) and 4M HCl in dioxane (10 mL) was carried out analogously to Example 91. Isolation, also in an analogous manner afforded the title compound (52 mg, 0.102 mmol) as an orange/yellow powder in 99% yield.

出典と根拠

ORDレコード
ord-c0c9a3ecd632422aa85fe7df93b505c4
出典データセット
uspto-grants-2006_11
特許番号
US07132533B2

関連ノート

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