Potassium Hydroxide → 5,6,7-Trimethoxy-1H-indole-2-carboxylic acid

HRID 720328

反応式

HRID 720328 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([O:18]C)=[O:17])=[CH:6]2.[OH-].[K+]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([OH:18])=[O:17])=[CH:6]2

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 4453649methyl 5,6,7-trimethoxy-1H-indole-2-carboxylate

生成物 1

HCID 8210525,6,7-Trimethoxy-1H-indole-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl 5,6,7-trimethoxyindole-2-carboxylate (700 mg) was dissolved in methanol (13 mL), potassium hydroxide powder (450 mg) was added to the solution, and the mixture was stirred for 3 hours under reflux. After allowing the reaction mixture to cool, it was concentrated under reduced pressure, and water was added to the residue. The resultant water layer was washed with ether and then neutralized with diluted hydrochloric acid. Crystals deposited were collected by filtration and dried to obtain the title compound.

後処理

  1. temperatureunder reflux
  2. temperatureto cool
  3. concentrationit was concentrated under reduced pressure, and water
  4. additionwas added to the residue
  5. washThe resultant water layer was washed with ether
  6. filtrationCrystals deposited were collected by filtration
  7. customdried

出典と根拠

ORDレコード
ord-ef47eda3e0f746f9ab94ee01fb7f597b
出典データセット
uspto-grants-2006_11
特許番号
US07135473B2

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