2-Hydroxymethyl-1-methyl-4,5,6-trimethoxyindole → 1-Methyl-4,5,6-trimethoxyindole-2-carboaldehyde
反応式
[OH:1][CH2:2][C:3]1[N:4]([CH3:18])[C:5]2[C:10]([CH:11]=1)=[C:9]([O:12][CH3:13])[C:8]([O:14][CH3:15])=[C:7]([O:16][CH3:17])[CH:6]=2>C1C=CC=CC=1.[O-2].[O-2].[Mn+4]>[CH3:18][N:4]1[C:5]2[C:10](=[C:9]([O:12][CH3:13])[C:8]([O:14][CH3:15])=[C:7]([O:16][CH3:17])[CH:6]=2)[CH:11]=[C:3]1[CH:2]=[O:1]参加物
4
実験手順
2-Hydroxymethyl-1-methyl-4,5,6-trimethoxyindole (861 mg) was dissolved in benzene (50 mL), activated manganese dioxide (8.7 g) was added to the solution, and the mixture was stirred at room temperature for 2 hours. After the reaction mixture was filtered, and the filtrate was concentrated, the residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:2) to obtain the title compound.