Sodium Bicarbonate → HCID 135828224、化合物

HRID 720452ノート

反応式

HRID 720452 の反応式
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[C:5]([C:17]#[N:18])=[C:4]([SH:19])[N:3]=1.Br.Br[CH2:22][CH2:23][NH2:24].C([O-])(O)=O.[Na+]>CN(C=O)C.Cl>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)[C:5]([C:17]#[N:18])=[C:4]([S:19][CH2:22][CH2:23][NH2:24])[N:3]=1

参加物

6

反応物 3

HCID 516892Sodium BicarbonateHCID 27742172-Bromoethylamine hydrobromideHCID 178510481HCID 178510481、化合物

生成物 1

HCID 135828224HCID 135828224、化合物

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 6228Dimethylformamide溶媒

実験手順

268 mg (1 mmol) of 2-amino-4-(4-hydroxyphenyl)-6-sulfanyl-3,5-pyridinedicarbonitrile, 105 mg (1 mmol) of 2-bromoethylamine hydrobromide and 168 mg (2 mmol) of NaHCO3 are stirred in 1 ml of DMF for 1 hour. The entire mixture is diluted with a few milliliters of 1N HCl. The crystals are filtered off with suction and dried under reduced pressure.

後処理

  1. filtrationThe crystals are filtered off with suction
  2. customdried under reduced pressure

出典と根拠

ORDレコード
ord-2342196d5d1f465ba0c3943b3caf9250
出典データセット
uspto-grants-2006_11
特許番号
US07135486B1

反応ノート

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