Acetyl bromide → 4-Bromo-1-oxo-2-(pyridin-2-yl)-1lambda~5~-pyridine

HRID 72066

反応式

HRID 72066 の反応式
[N+]([C:4]1[CH:5]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[N+:7]([O-:10])=[CH:8][CH:9]=1)([O-])=O.C([Br:20])(=O)C>C(O)(=O)C>[Br:20][C:4]1[CH:5]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[N+:7]([O-:10])=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 10482Acetyl bromideHCID 33312824-Nitro-2,2'-bipyridine-N-oxide

生成物 1

HCID 181727784-Bromo-1-oxo-2-(pyridin-2-yl)-1lambda~5~-pyridine収率 95%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To 4-nitro-2,2′-bipyridyl-N-oxide (Wenkert, D.; Woodward, R. B. J. Org. chem. 48, 283 (1983)) (5 g) dissolved in 30 mL acetic acid in a 100 ml round bottom flask was added 16 mL acetyl bromide. The yellow mixture was refluxed for 1.5 h and then rotovaporated to dryness. The resulting light yellow solid was sufficiently pure enough for the next step without further purification. Yield: 95%

後処理

  1. temperatureThe yellow mixture was refluxed for 1.5 h
  2. customThe resulting light yellow solid was sufficiently pure enough for the next step without further purification

出典と根拠

ORDレコード
ord-1eff567b02ea4910882571a0bc65cf5e
出典データセット
uspto-grants-2014_09
特許番号
US08828204B2

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