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3,4-Diaminobenzonitrile → 2-Hydroxyquinoxaline-6-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-Diaminobenzonitrile | HCID 737285 | — |
| 反応物 | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 2-Hydroxyquinoxaline-6-carbonitrile | HCID 45121730 | — |
反応手順
To a stirred solution of 3,4-diaminobenzonitrile (5.00 g, 37.6 mmol) in 5% aq HCl (20 mL) was added glyoxilic acid monohydrate (4.32 g, 46.9 mmol). The mixture was stirred overnight at rt and filtered. The filter cake was washed with water and MeOH to afford 2-oxo-1,2-dihydroquinoxaline-6-carbonitrile as a grey solid which was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08828985B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-f4d6d8765b134ec98904a66135422cd8 |
| 出典メモ | uspto-grants-2014_09 |