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Hydrochloric Acid → (R)-2-adamantyl 3-aminopyrrolidine-1-carboxylate HCl salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | (3R)-(2-adamantyl) 3-(tert-butoxycarbonylamino)pyrrolidine-1-carboxylate | HCID 52944645 | — |
| 生成物 | (R)-2-adamantyl 3-aminopyrrolidine-1-carboxylate HCl salt | HCID 67155574 | — |
反応手順
To (3R)-(2-adamantyl) 3-(tert-butoxycarbonylamino)pyrrolidine-1-carboxylate (0.43 g, 1.18 mmol) was added 4 M HCl in dioxane (5 mL, 20 mmol). The mixture was stirred at rt for 1 h and concentrated to afford (R)-2-adamantyl 3-aminopyrrolidine-1-carboxylate HCl salt (0.45 g) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08828985B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-32c85c6786cb4689912a002dee8a1170 |
| 出典メモ | uspto-grants-2014_09 |