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Potassium Iodide → 1-(6-Chlorobenzotriazol-1-yl)-propan-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Chloroacetone | HCID 6571 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | HCID 178418767 | HCID 178418767 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 1-(6-Chlorobenzotriazol-1-yl)-propan-2-one | HCID 22020252 | — |
| 生成物 | 1-(5-Chlorobenzotriazol-1-yl)-propan-2-one | HCID 22020253 | — |
反応手順
A mixture of 5 g of 5-chlorobenzotriazole, 1.4 g of chloroacetone, 5.1 g of potassium carbonate and 0.5 g of potassium iodide is stirred into 50 ml of acetone at room temperature for 48 h. The mixture is subsequently filtered, the filtrate concentrated by evaporation in a vacuum, and the residue purified by flash chromatography. In this way, two isomeric products, 1-(5-chlorobenzotriazol-1-yl)-propan-2-one and 1-(6-chlorobenzotriazol-1-yl)-propan-2-one, are isolated in approximately the same quantities, the first of which is then used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084280B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-1afeb603539e4cb68b366cc59118d27f |
| 出典メモ | uspto-grants-2006_08 |