4,4,5,5-Tetramethyl-2-(4-nitrophenyl)-1,3,2-dioxaborolane → (S)-3-methyl-4-(1-methyl-5-(4-nitrophenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl)morpholine

HRID 72188

反応式

HRID 72188 の反応式
C(NC(NC1C=CC([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]3[CH3:29])[C:16]3[N:21]([CH3:22])[N:20]=[CH:19][C:17]=3[N:18]=2)=CC=1)=O)C.[N+:30]([C:33]1[CH:38]=[CH:37][C:36](B2OC(C)(C)C(C)(C)O2)=[CH:35][CH:34]=1)([O-:32])=[O:31]>>[CH3:29][C@H:24]1[CH2:25][O:26][CH2:27][CH2:28][N:23]1[C:15]1[C:16]2[N:21]([CH3:22])[N:20]=[CH:19][C:17]=2[N:18]=[C:13]([C:36]2[CH:35]=[CH:34][C:33]([N+:30]([O-:32])=[O:31])=[CH:38][CH:37]=2)[N:14]=1

参加物

3

反応物 2

HCID 27735554,4,5,5-Tetramethyl-2-(4-nitrophenyl)-1,3,2-dioxaborolaneHCID 51039139(S)-1-ethyl-3-(4-(1-methyl-7-(3-methylmorpholino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea

生成物 1

HCID 58222489(S)-3-methyl-4-(1-methyl-5-(4-nitrophenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl)morpholine

実験手順

This compound was prepared in an analogous fashion to (S)-1-ethyl-3-(4-(1-methyl-7-(3-methylmorpholino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea, using 4-nitrophenylboronic acid pinacol ester as the starting material. 1H NMR (CDCl3, 400 MHz) δ ppm 8.62 (d, J=9.0 Hz, 2H), 8.32 (d, J=9.0 Hz, 2H), 8.22 (s, 1H), 4.27 to 4.17 (m, 4H), 4.08 to 3.95 (m, 2H), 3.93 to 3.82 (m, 1H), 3.79 to 3.67 (m, 2H), 3.60 to 3.50 (m, 1H), 1.38 (d, J=6.6 Hz, 3H).

出典と根拠

ORDレコード
ord-b6c44d9f65d54517b600d3690276d509
出典データセット
uspto-grants-2014_09
特許番号
US08828990B2

関連ノート

読み込み中…