Potassium Carbonate → Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine

HRID 72194

反応式

HRID 72194 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[CH:3]=1.[CH3:12][N:13]([CH3:19])[CH:14]1[CH2:18][CH2:17][NH:16][CH2:15]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:12][N:13]([CH3:19])[CH:14]1[CH2:18][CH2:17][N:16]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[CH:3]=2)[CH2:15]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 949565-Fluoro-2-nitrotolueneHCID 27585193-(Dimethylamino)pyrrolidine

生成物 1

HCID 68977058Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 4-fluoro-2-methyl-1-nitrobenzene (13.6 g), dimethylpyrrolidin-3-ylamine (10.0 g), potassium carbonate (12 g) and DMF (100 mL) was stirred at room temperature for 4 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way; MS (ESI): 250 (M+H+).

後処理

  1. customThe reaction mixture was partitioned between water and ethyl acetate
  2. customThe organic phase was dried
  3. concentrationconcentrated
  4. customThe product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way

出典と根拠

ORDレコード
ord-0875dc4f41854179839123d1593d5957
出典データセット
uspto-grants-2014_09
特許番号
US08828991B2

関連ノート

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