Dimethylformamide dimethyl acetal → 2-[(Dimethylamino)methylene]-5,5-dimethylcyclopentanone
反応式
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[CH3:9][C:10]1([CH3:16])[CH2:14][CH2:13][CH2:12][C:11]1=[O:15]>>[CH3:6][N:4]([CH:3]=[C:12]1[CH2:13][CH2:14][C:10]([CH3:16])([CH3:9])[C:11]1=[O:15])[CH3:5]参加物
3
実験手順
A mixture of N,N-dimethylformamide dimethyl acetal (67 mL, 503 mmol) and 2,2-dimethylcyclopentanone (10 g, 90 mmol) was heated at reflux for 2 days. The reaction mixture was then cooled down to room temperature and concentrated. Water (˜380 mL) was added to the residue, and the resulting solution was extracted with methylene chloride. The organic layer was separated, dried over MgSO4 and concentrated to give the title compound (12.5 g) as a yellow-orange oil.
後処理
- temperaturewas heated
- temperatureat reflux for 2 days
- concentrationconcentrated
- additionWater (˜380 mL) was added to the residue
- extractionthe resulting solution was extracted with methylene chloride
- customThe organic layer was separated
- dry with materialdried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-1228a11e329049219729c13590d0d8db
- 出典データセット
- uspto-grants-2006_11
- 特許番号
- US07138361B2
反応ノート
読み込み中…