Cyclobutylamine → HCID 57633529、化合物

HRID 722148ノート

反応式

HRID 722148 の反応式
[S:1]([O:5][C:6]1[C:7](=[CH:9][CH:10]=[CH:11][CH:12]=1)[OH:8])([OH:4])(=[O:3])=O.[CH:13]1([NH2:17])[CH2:16][CH2:15][CH2:14]1>C(Cl)Cl.CN(C=O)C>[OH:8][C:7]1[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=1[O:5][S:1](=[O:3])(=[O:4])[NH:17][CH:13]1[CH2:16][CH2:15][CH2:14]1

参加物

5

反応物 2

HCID 75645CyclobutylamineHCID 30838792-Hydroxyphenyl hydrogen sulfate

生成物 1

HCID 57633529HCID 57633529、化合物

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 6344Dichloromethane溶媒

実験手順

Cyclobutyl-sulfamic acid 2-hydroxy-phenyl ester was prepared by adding a solution of catechol sulphate (1.32 g, 7.7 mmol) in DCM (2 ml) to a stirred solution of cyclobutylamine (600 μl, 7.0 mmol) and TEA (1.07 ml, 7.7 mmol) in DMF at 0° C., and stirring for 3 hours at this temperature. The mixture was quenched with 1M HCl (50 ml) and extracted with diethyl ether. The organic extract was washed with water, brine, dried and concentrated to dryness. Quantitative yield.

後処理

  1. customThe mixture was quenched with 1M HCl (50 ml)
  2. extractionextracted with diethyl ether
  3. extractionThe organic extract
  4. washwas washed with water, brine
  5. customdried
  6. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-cc413cc509c3422c8cffb0a66d4b3418
出典データセット
uspto-grants-2006_11
特許番号
US07138400B2

反応ノート

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